When a network is broken — an electrical grid, the World Wide Web, your neurological system — one math model created by a PhD student at Northwestern University suggests that the best way to fix it may be to break it a little more. 'Take the web of interactions within a cell. If you knock out an important gene, you will significantly damage the cell's growth rate. However, it is possible to repair this damage not by replacing the lost gene, which is a very challenging task, but by removing additional genes. The key lies in finding the specific changes that would bring a network from the undesirable state A to the preferred state B. Cornelius's mathematical model (abstract) provides a general method to pinpoint those changes in any network, from the metabolism of a single cell to an entire food web.
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